CALL FOR PAPERS Comparative Genomics Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis

نویسندگان

  • M. Jastroch
  • K. W. Withers
  • S. Taudien
  • P. B. Frappell
  • M. Helwig
  • T. Fromme
  • V. Hirschberg
  • G. Heldmaier
  • B. M. McAllan
  • B. T. Firth
  • T. Burmester
  • M. Platzer
  • M. Klingenspor
چکیده

M. Jastroch, K. W. Withers, S. Taudien, P. B. Frappell, M. Helwig, T. Fromme, V. Hirschberg, G. Heldmaier, B. M. McAllan, B. T. Firth, T. Burmester, M. Platzer, and M. Klingenspor Department of Animal Physiology, Faculty of Biology, Philipps-Universität Marburg, Marburg, Germany, Department of Biological and Physical Sciences, University of Southern Queensland, Toowoomba, Queensland, Australia, Genome Analysis, Leibniz-Institute for Age Research-Fritz Lipmann Institute, Jena, Germany; Adaptational and Evolutionary Respiratory Physiology Laboratory, Department of Zoology, La Trobe University, Melbourne 3086, Victoria; Physiology, School of Medical Sciences, The University of Sydney, Sydney, New South Wales; Discipline of Anatomical Sciences, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia; and Institute of Zoology, Biozentrum Grindel, University of Hamburg, Hamburg, Germany

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Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis.

Brown adipose tissue expressing uncoupling protein 1 (UCP1) is responsible for adaptive nonshivering thermogenesis giving eutherian mammals crucial advantage to survive the cold. The emergence of this thermogenic organ during mammalian evolution remained unknown as the identification of UCP1 in marsupials failed so far. Here, we unequivocally identify the marsupial UCP1 ortholog in a genomic li...

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Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis.

Uncoupling proteins (UCPs) increase proton leakage across the inner mitochondrial membrane. Thereby, UCP1 in brown adipose tissue dissipates proton motive force as heat. This mechanism of nonshivering thermogenesis is considered as a monophyletic trait of endothermic placental mammals that emerged about 140 million years ago and provided a crucial advantage for life in the cold. The paralogues ...

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تاریخ انتشار 2008